Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

WIT: integrated system for high-throughput genome sequence analysis and metabolic reconstruction.

R Overbeek¹, N Larsen, G D Pusch

¹Integrated Genomics Inc., 2201 W. Campbell Park Drive, Chicago, IL 60612, USA. ross@integratedgenomics.com

Nucleic Acids Research

|December 11, 1999

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Response to the comment on "Robotic-controlled laser osteotome versus manually controlled osteotomy for interdental osteotomies: a cadaveric study".

International journal of oral and maxillofacial surgery·2026

Same author

Enhancing the sensory and nutritional properties of faba bean protein through fermentation with lactic acid bacteria and Bacillus spp.

International journal of food microbiology·2025

Same author

Robotic-controlled laser osteotome versus manually controlled osteotomy for interdental osteotomies: a cadaveric study.

International journal of oral and maxillofacial surgery·2025

Same author

Iodine uptake of adrenal glands: A novel and reliable spectral dual-layer computed tomographic-derived biomarker for acute septic shock.

European journal of radiology·2022

Same author

Central vein sign in patients with inflammatory lesion of the upper cervical spinal cord on susceptibility weighted imaging at 3 tesla. Preliminary results.

Magnetic resonance imaging·2022

Same author

Efficacy and safety in the use of stent-retrievers for treatment of cerebral vasospasms after subarachnoid hemorrhage.

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences·2022

The What Is There (WIT) system aids comparative genome analysis and metabolic reconstruction using data from ~40 genomes. It helps assign gene functions and understand organism physiology through integrated genomic data.

Area of Science:

Genomics
Bioinformatics
Systems Biology

Background:

Comparative analysis of sequenced genomes is crucial for understanding biological systems.
Metabolic reconstruction provides insights into organismal physiology.

Purpose of the Study:

To introduce the What Is There (WIT) system for comparative genome analysis.
To enable metabolic reconstruction using genomic sequences and metabolic modules.
To facilitate gene function assignment and genome overview development.

Main Methods:

Utilizing sequence homologies and ORF-clustering algorithms.
Analyzing relative gene positions on chromosomes.
Mapping gene products to metabolic pathways for reconstruction.

Related Experiment Videos

Main Results:

The WIT system integrates data from approximately 40 diverse, completed genomes.
Enables functional annotation of genes within genomes.
Facilitates the development of comprehensive genome overviews.

Conclusions:

The WIT system supports comparative genomics and metabolic reconstruction.
Integration of diverse genomes enhances understanding of organismal physiology.
WIT is a valuable tool for genomic and metabolic research.