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Axeldb: a Xenopus laevis database focusing on gene expression.

N Pollet1, H A Schmidt, V Gawantka

  • 1Department of Molecular Embryology, Deutsches Krebsforschungszentrum, lm Neuenheimer Feld 280, D-69120 Heidelberg, Germany. n.pollet@dkfz-heidelberg.de

Nucleic Acids Research
|December 11, 1999
PubMed
Summary

Axeldb is a database that integrates gene expression and DNA sequence data from Xenopus laevis embryos. This resource facilitates comparative analysis of gene expression patterns and aids future research integration.

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Area of Science:

  • Developmental Biology
  • Genomics
  • Bioinformatics

Background:

  • Large-scale in situ hybridization studies generate vast amounts of gene expression data.
  • Integrating and analyzing this data is crucial for understanding embryonic development.
  • Existing databases may lack comprehensive Xenopus laevis expression information.

Purpose of the Study:

  • To create a centralized database (Axeldb) for Xenopus laevis gene expression and DNA sequence data.
  • To facilitate comparative analysis of gene expression patterns.
  • To integrate diverse data types including literature, sequences, and images.

Main Methods:

  • Utilized an ACEDB database system for data organization.
  • Integrated data from large-scale in situ hybridization studies.

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  • Developed web accessibility for data retrieval and analysis.

    • Main Results:

    • Axeldb stores and integrates gene expression patterns and DNA sequences for Xenopus laevis.
    • The database enables comparison of expression patterns across different genes.
    • Provides access to literature, cDNA clones, nucleotide sequences, and expression images.

    Conclusions:

    • Axeldb serves as a valuable resource for Xenopus laevis developmental biology research.
    • The database structure supports comprehensive analysis and comparison of gene expression data.
    • Future developments aim to enhance interoperability with other databases and literature data.