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MitBASE : a comprehensive and integrated mitochondrial DNA database. The present status.

M Attimonelli1, N Altamura, R Benne

  • 1Dipartimento di Biochimica e Biologia Molecolare, Università degli Studi di Bari, 70126 Bari, Italy. marcella@area.ba.cnr.it

Nucleic Acids Research
|December 11, 1999
PubMed
Summary

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This summary is machine-generated.

MitBASE is a comprehensive mitochondrial DNA database integrating diverse organism data. It aids research into mitochondrial genetic diseases and intraspecies diversity.

Area of Science:

  • Bioinformatics
  • Genomics
  • Molecular Biology

Background:

  • Mitochondrial DNA (mtDNA) data is crucial for understanding various biological processes and diseases.
  • Existing mtDNA databases were fragmented, hindering comprehensive analysis.
  • Mitochondrial biogenesis involves nuclear genes, requiring integrated data.

Purpose of the Study:

  • To create an integrated, comprehensive database of mitochondrial DNA (mtDNA) data.
  • To provide a unified interface for diverse organism mtDNA and related nuclear genes.
  • To support research in mitochondrial genetic diseases and intraspecies diversity.

Main Methods:

  • Integrated diverse mtDNA databases (Plant, Vertebrate, Invertebrate, Human, Protist, Fungal) and a pilot nuclear gene database.

Related Experiment Videos

  • Structured value-added information, including protist mtDNA genome editing and human mtDNA variant pathology.
  • Integrated disparate databases (Access, File Maker Pro, flat-file) using ORACLE.
  • Developed ad hoc retrieval systems tailored to database specificities.

    • Main Results:

    • Established MitBASE, a comprehensive, integrated mtDNA database.
    • Includes data from various organisms, intraspecies variants, and mutants.
    • Provides structured, value-added information for enhanced research utility.
    • Database is accessible via the European Bioinformatics Institute (EBI).

    Conclusions:

    • MitBASE offers a unified resource for mitochondrial DNA research.
    • Facilitates studies on mitochondrial genetic diseases and intraspecies diversity.
    • Supports both basic and applied research in biotechnology and related fields.