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Related Experiment Videos

The prostate expression database (PEDB): status and enhancements in 2000.

P S Nelson1, N Clegg, B Eroglu

  • 1Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. pnelson@fhcrc.org

Nucleic Acids Research
|December 11, 1999
PubMed
Summary

The Prostate Expression Database (PEDB) provides access to over 55,000 human prostate expressed sequence tags (ESTs). This resource facilitates gene expression analysis and includes functional categorization and proteome data.

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Area of Science:

  • Genomics
  • Bioinformatics
  • Molecular Biology

Background:

  • Gene expression analysis is crucial for understanding prostate biology and disease.
  • Existing resources for prostate gene expression data were limited in scope and accessibility.

Purpose of the Study:

  • To establish a comprehensive online database for human prostate gene expression data.
  • To develop tools for analyzing and comparing gene expression patterns across different prostate tissues and conditions.

Main Methods:

  • Archiving over 55,000 expressed sequence tags (ESTs) from 43 cDNA libraries.
  • Developing a curated relational database with detailed library information.
  • Implementing a Virtual Expression Analysis Tool (VEAT) for comparative analysis.

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Main Results:

  • PEDB provides access to a large collection of human prostate ESTs.
  • The database enables functional categorization of EST assemblies and creation of transcriptomes.
  • Proteome information from prostate cancer cell lines has been integrated.

Conclusions:

  • PEDB serves as a valuable resource for researchers studying human prostate gene expression.
  • Enhanced features facilitate deeper analysis of prostate transcriptomes and proteomes.
  • The database supports comparative genomics and disease-related research.