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The ASTRAL compendium for protein structure and sequence analysis.

S E Brenner1, P Koehl, M Levitt

  • 1Department of Structural Biology, Stanford University, Fairchild Building D-109, Stanford, CA 94305-5126, USA. brenner@compbio.berkeley.edu

Nucleic Acids Research
|December 11, 1999
PubMed
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The ASTRAL compendium offers protein sequence and structure analysis tools. It includes databases for structural alignments and protein domain sequences, aiding researchers in understanding protein characteristics.

Area of Science:

  • Bioinformatics
  • Structural Biology
  • Computational Biology

Background:

  • Protein structure analysis is crucial for understanding biological function.
  • Databases and tools are needed to manage and interpret large amounts of structural data.

Purpose of the Study:

  • To introduce the ASTRAL compendium, a resource for protein structure and sequence analysis.
  • To highlight the utility of SPACI scores, structural alignments, and sequence-map files.

Main Methods:

  • The ASTRAL compendium integrates PDB sequence-map files with SCOP database information.
  • It provides structural alignments and SPACI scores for protein domain analysis.
  • Databases of selected protein domain subsets with varying similarity measures are available.

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Main Results:

  • ASTRAL offers comprehensive databases and tools for analyzing protein structures via sequences.
  • SPACI scores summarize protein structure characteristics.
  • Structural alignments database identifies residue equivalencies in superimposed domains.

Conclusions:

  • The ASTRAL compendium facilitates protein structure analysis through sequence-based methods.
  • It provides valuable resources for researchers in structural biology and bioinformatics.
  • Access to ASTRAL is available at http://astral.stanford.edu/