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Related Experiment Videos

Assigning genomic sequences to CATH.

F M Pearl1, D Lee, J E Bray

  • 1Department of Biochemistry, University College London, University of London, Gower Street, London WC1E 6BT, UK. frances@biochem.ucl.ac.uk

Nucleic Acids Research
|December 11, 1999
PubMed
Summary
This summary is machine-generated.

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The CATH protein domain database (version 1.6) classifies protein structures into evolutionary families and structural groups. New features improve speed, accuracy, and functional annotation for protein relatives.

Area of Science:

  • Structural bioinformatics
  • Computational biology
  • Protein domain classification

Background:

  • The CATH database provides a hierarchical classification of protein domains.
  • It groups domains into evolutionary families and structural groupings.

Purpose of the Study:

  • To report the latest release (version 1.6) of the CATH protein domains database.
  • To introduce new developments including the CATH-PFDB and an updated DHS.

Main Methods:

  • Hierarchical classification of 18,577 protein domains.
  • Identification of 1,028 homologous superfamilies, 672 fold groups, and 35 architectures.
  • Generation of 3D templates for improved database updates and validation.

Main Results:

Related Experiment Videos

  • Database version 1.6 includes 18,577 domains, 1,028 superfamilies, 672 fold groups, and 35 architectures.
  • New 3D templates enhance speed and accuracy of database updates.
  • CATH-PFDB associates 1D sequences with 3D superfamilies; DHS provides functional annotations for relatives.

Conclusions:

  • The CATH database, with its new features, offers improved tools for protein domain classification and analysis.
  • The CATH-PFDB and updated DHS facilitate the study of sequence-structure-function relationships.
  • These resources aid in understanding functional variation within protein superfamilies and identifying conserved properties in new relatives.