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The 1999 SWISS-2DPAGE database update.

C Hoogland1, J C Sanchez, L Tonella

  • 1Swiss Institute of Bioinformatics, 1 rue Michel-Servet, CH-1211 Genève 4, Switzerland. christine.hoogland@isb-sib.ch

Nucleic Acids Research
|December 11, 1999
PubMed
Summary
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SWISS-2DPAGE is a vital protein database featuring 24 reference maps for human, mouse, and microbial proteomes. It now includes 2,824 identified spots and 614 protein entries, enhancing proteomic research.

Area of Science:

  • Proteomics
  • Bioinformatics
  • Molecular Biology

Background:

  • SWISS-2DPAGE is a long-standing annotated two-dimensional polyacrylamide gel electrophoresis (2-DE) database.
  • Established in 1993, it serves as a crucial resource for protein identification and analysis.

Purpose of the Study:

  • To report on the recent updates and expanded content of the SWISS-2DPAGE database.
  • To highlight improvements in data accessibility and integration with other proteomics resources.

Main Methods:

  • Curating and integrating 2-DE reference maps from various biological sources (human, mouse, yeast, bacteria).
  • Identifying protein spots and linking them to protein entries and sequences.
  • Implementing new functionalities and cross-references within the ExPASy proteomics server.

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Main Results:

  • The database currently holds 24 reference maps.
  • It features 2,824 identified spots, corresponding to 614 distinct protein entries.
  • Three new maps were added, and several existing maps were updated, with enhanced cross-referencing.

Conclusions:

  • SWISS-2DPAGE continues to be an expanding and valuable resource for the proteomics community.
  • Recent improvements enhance data accessibility and integration, supporting advanced proteomic research.