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Related Experiment Videos

ASDB: database of alternatively spliced genes.

I Dralyuk1, M Brudno, M S Gelfand

  • 1National Energy Research Scientific Computing Center, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

Nucleic Acids Research
|December 11, 1999
PubMed
Summary

The Alternative Splicing Data Base (ASDB) version 2.1 offers a comprehensive collection of protein and DNA sequences, facilitating research into alternative splicing variants. It provides a search engine for exploring gene and protein data, linking to all identified variants.

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Area of Science:

  • Bioinformatics
  • Molecular Biology
  • Genomics

Background:

  • Alternative splicing is a key mechanism in gene expression regulation.
  • Understanding splice variants is crucial for comprehending protein diversity and function.
  • Existing databases may lack comprehensive integration of splicing data.

Purpose of the Study:

  • To present version 2.1 of the Alternative Splicing Data Base (ASDB).
  • To provide an integrated resource for protein and DNA sequences related to alternative splicing.
  • To enhance data accessibility and facilitate variant exploration.

Main Methods:

  • Data compilation from SWISS-PROT and GenBank.
  • Clustering of protein entries based on alternatively spliced variants.

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  • Annotation of complete genes with alternative splicing information.
  • Development of a search engine for querying SWISS-PROT and GenBank fields.

    • Main Results:

    • ASDB version 2.1 contains 1922 protein and 2486 DNA sequences.
    • Protein entries are clustered to represent alternatively spliced variants of single genes.
    • DNA division includes complete genes with annotated alternative splicing.
    • The search engine enables cross-database querying and variant linkage.

    Conclusions:

    • ASDB provides a valuable, updated resource for studying alternative splicing.
    • The integrated database and search functionality streamline variant analysis.
    • Facilitates research in gene expression and protein diversity.