Related Experiment Videos
The homeodomain resource: a prototype database for a large protein family
S Banerjee-Basu1, J F Ryan, A D Baxevanis
1Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Nucleic Acids Research
|December 11, 1999
Summary
The Homeodomain Resource (Release 2.0) offers a comprehensive database of homeodomain protein sequences, structures, and genomic data. This updated resource aids researchers studying homeodomain proteins and related genetic disorders.
Area of Science:
- Genomics
- Structural Biology
- Bioinformatics
Background:
- Homeodomain proteins play crucial roles in development and disease.
- A centralized, curated resource for homeodomain information is needed.
- Previous versions of the Homeodomain Resource have been valuable to the research community.
Purpose of the Study:
- To update and expand the Homeodomain Resource with new data and features.
- To provide researchers with easy access to comprehensive homeodomain information.
- To improve database searching and data management capabilities.
Main Methods:
- Collection and annotation of non-redundant protein sequences.
- Inclusion of experimentally derived three-dimensional structures.
- Integration of genomic information, including homeobox loci linked to human disorders.
- Development of a user-friendly search engine with a graphical interface.
- Implementation of automated methods for database maintenance and data management.
Main Results:
- Release 2.0 contains 765 full-length homeodomain-containing sequences.
- Includes 29 experimentally derived structures and 116 homeobox loci associated with human genetic disorders.
- Entries are hyperlinked to source databases for easy data retrieval.
- Features an enhanced search engine for customized data set assembly.
- Incorporates automated methods for efficient database operation.
Conclusions:
- The updated Homeodomain Resource provides an invaluable, integrated platform for homeodomain research.
- Enhanced data accessibility and search functionalities facilitate scientific discovery.
- The resource supports research into the function of homeodomain proteins and their role in human diseases.