BDNF atelocollagen mini-pellet accelerates facial nerve regeneration
E Kohmura1, T Yuguchi, T Yoshimine
1Department of Neurosurgery, Osaka University Graduate School of Medicine, 2-2 E6 Yamadaoka, Suita, Japan. ekohmura@nsurg.med.osaka-u.ac.jp
Brain Research
|December 11, 1999
Abstract:
We investigated the effect of BDNF mini-pellet on the GAP-43 mRNA expression and functional status of facial nerve in a rat model of facial nerve transection and immediate repair. The facial function started to recover at 17 days in the placebo group and 14 days in the BDNF group. BDNF group had shorter period of increased GAP-43 mRNA expression than the placebo group. Topically applied BDNF may accelerate the facial nerve regeneration.
