Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Similarity pattern analysis in mutational distributions.

N N Khromov-Borisov1, I B Rogozin, J A Pêgas Henriques

  • 1Institute of Cytology and Genetics, Russian Academy of Sciences, Novosibirsk, Russia. nikita@dna.cbiot.ufrgs.br

Mutation Research
|December 11, 1999
PubMed
Summary

Similarity Pattern Analysis (SPAN) effectively analyzes mutational distributions by clustering mutagens and genetic profiles. This statistical method reveals relationships between mutagens and their induced mutations, aiding in understanding mutagenicity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Interchangeability of different indirect methods for determining body composition].

Problemy endokrinologii·2025
Same author

[Physical training in patients with chronic heart failure: level of involvement, as well as psychosocial, anamnestic and iatrogenic factors that determine the motivation to practice].

Kardiologiia·2020
Same author

Nonstructural p26 proteins encoded by the 3'-proximal genes of velariviruses and criniviruses are orthologs.

Archives of virology·2019
Same author

[Genetic risk assessment of the joint effect of several genes: Critical appraisal].

Genetika·2018
Same author

[Correct statistical analysis of genotype frequencies for UCP and PPAR gene families in residents of besieged Leningrad and the control group].

Advances in gerontology = Uspekhi gerontologii·2017
Same author

Retention of duplicated ITAM-containing transmembrane signaling subunits in the tetraploid amphibian species Xenopus laevis.

Developmental and comparative immunology·2015

Area of Science:

  • Genetics
  • Statistical Analysis
  • Molecular Biology

Background:

  • Mutational distributions (MDs) require robust analytical methods.
  • Understanding mutagenic mechanisms relies on comparing mutation profiles across different agents and genetic contexts.

Purpose of the Study:

  • To demonstrate the validity and applicability of Similarity Pattern Analysis (SPAN) for studying mutational distributions.
  • To analyze mutational spectra (MS) from Escherichia coli and Neurospora crassa using SPAN.

Main Methods:

  • Applied SPAN to analyze mutational spectra data as large two-way contingency tables.
  • Utilized Kastenbaum-Hirotsu squared distance (KHi(2)) to measure profile similarity.
  • Developed the COLLAPSE computer program to facilitate profile clustering into 'collapsets'.

Related Experiment Videos

Main Results:

  • SPAN successfully identified similarity patterns in both Escherichia coli (lacI gene) and Neurospora crassa (ad-3 region) datasets.
  • Five distinct clusters (collapsets) of mutagens were identified in the Neurospora crassa data based on their mutational profiles.
  • Confirmed dose-dependency of mutational distributions for X-ray-induced mutations and identified similarities between mutagens with comparable modes of action.

Conclusions:

  • SPAN is a powerful and interpretable methodology for analyzing mutational spectra.
  • The revealed similarity patterns provide insights into mutagen mechanisms and their effects on DNA.
  • SPAN, when combined with descriptive cluster analysis, offers a fruitful approach for MS analysis.