Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Urea kinetics with dialyzer reuse--a prospective study.

N R Sridhar1, K Ferrand, D Reger

  • 1State University of New York at Buffalo School of Medicine, Department of Medicine, Buffalo General Hospital, Buffalo, NY, USA.

American Journal of Nephrology
|December 11, 1999
PubMed
Summary

Dialyzer reuse up to eight times showed no significant impact on urea clearance (KT/V) across three membrane types. This study supports the safety and efficacy of dialyzer reprocessing for hemodialysis patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Access to Primary Healthcare by Ukrainian Beneficiaries of Temporary Protection in Rural Communities.

Irish medical journal·2025
Same author

Product innovation of non-alcoholic barley-based teas and kombucha: Consumer preferences and emotional responses.

Journal of food science·2025
Same author

Validation of the European Oncology toolkit for the self-assessment of Quality of Life (EUonQoL-Kit) in cancer patients and survivors: study protocol of a pan European survey.

BMC public health·2024
Same author

Supporting GPs and people with hypertension to maximise medication use to control blood pressure: a pilot cluster RCT of the MIAMI intervention.

BMC primary care·2024
Same author

Cold water swimming and its potential health benefits - a qualitative study of participants' views and experiences.

Irish medical journal·2023
Same author

Towards an integrated blood pressure self-monitoring solution for stroke/TIA in Ireland: a mixed methods feasibility study for the TASMIN5S IRL randomised controlled trial.

Pilot and feasibility studies·2023

Area of Science:

  • Nephrology
  • Biomedical Engineering
  • Materials Science

Background:

  • Dialyzer reuse is a common practice to reduce healthcare costs.
  • Concerns exist regarding the potential impact of reuse on dialyzer performance and patient safety.
  • Standardized protocols are crucial for evaluating dialyzer reuse efficacy.

Purpose of the Study:

  • To prospectively evaluate the effect of dialyzer reuse on urea clearance (KT/V).
  • To assess performance across three distinct dialyzer membrane types under standardized conditions.
  • To determine the safety and reliability of hemodialysis dialyzers reused up to eight times.

Main Methods:

  • Prospective study involving 3 membrane types (cellulose acetate, cuprophane, polysulfone).
  • Standardized heparinization (ACT) and blood processing volume (80 L).

Related Experiment Videos

  • Automated glutaraldehyde processing and fiber bundle integrity checks (>80% open).
  • KT/V and BUN measurements at 1st, 2nd, 4th, and 8th dialyzer uses.
  • Statistical analysis using 3-way ANOVA.

    • Main Results:

    • No significant differences in KT/V were observed between the 1st and subsequent uses (up to 8th use) for any membrane type.
    • Cellulose acetate dialyzers showed mean KT/V of 1.3 +/- 0.2 across uses.
    • Cuprophane dialyzers showed mean KT/V of 1.3-1.4 across uses.
    • Polysulfone dialyzers showed mean KT/V of 1.6-1.7 across uses.

    Conclusions:

    • Dialyzer reuse up to eight times does not compromise urea clearance.
    • The study validates a model for further research on dialyzer reuse and quality assurance.
    • Standardized reuse protocols ensure consistent dialyzer performance.