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Related Experiment Videos

Screening for acyclovir-resistant herpes simplex virus isolates from clinical samples.

I W Mah1, B I Kuo, H Y Wei

  • 1Department of Laboratory Medicine, Veterans General Hospital, Taipei.

Zhonghua Minguo Wei Sheng Wu Ji Mian Yi Xue Za Zhi = Chinese Journal of Microbiology and Immunology
|February 1, 1997
PubMed
Summary
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A study found a growing resistance to acyclovir in herpes simplex virus (HSV) strains isolated in Taipei. More HSV strains from the 1990s showed higher resistance levels compared to those from the 1980s.

Area of Science:

  • Virology
  • Antiviral Drug Resistance
  • Molecular Biology

Background:

  • Herpes simplex virus (HSV) infections remain a significant public health concern.
  • Acyclovir is a primary antiviral medication used for HSV treatment.
  • Monitoring antiviral resistance is crucial for effective disease management.

Purpose of the Study:

  • To determine the acyclovir susceptibility of HSV strains isolated in Taipei.
  • To investigate potential trends in acyclovir resistance over time.

Main Methods:

  • Plaque reduction assay was employed to determine ID50 and ID90 values.
  • Fifty HSV isolates were analyzed: 20 from 1980-1985 and 30 from 1990-1995.
  • Susceptibility testing was performed against acyclovir.

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Main Results:

  • Fifteen HSV isolates from the 1990s exhibited higher ID90 values than those from the 1980s.
  • This indicates a trend towards increased acyclovir resistance in recent HSV isolates.
  • The study identified a subset of HSV strains with reduced susceptibility to acyclovir.

Conclusions:

  • A growing acyclovir resistance in HSV strains was observed in Taipei.
  • The findings highlight the need for ongoing surveillance of antiviral resistance.
  • This trend may impact the efficacy of acyclovir in treating HSV infections.