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Typhlitis.

D R Urbach1, O D Rotstein

  • 1Department of Surgery, The Toronto Hospital and the University of Toronto.

Canadian Journal of Surgery. Journal Canadien De Chirurgie
|December 11, 1999
PubMed
Summary
This summary is machine-generated.

Typhlitis, an inflammatory condition, presents with right lower quadrant pain in immunocompromised patients. Conservative management with fluids and antibiotics is often effective, but surgery may be required for complications.

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Area of Science:

  • Gastroenterology
  • Oncology
  • Internal Medicine

Background:

  • Typhlitis, also known as neutropenic enterocolitis, is a serious gastrointestinal complication.
  • It primarily affects immunocompromised individuals, particularly those undergoing chemotherapy or stem cell transplantation.
  • Altered mucosal barrier function and inflammation in the right colon are key pathological features.

Purpose of the Study:

  • To comprehensively review the pathophysiological characteristics of typhlitis.
  • To outline current management strategies for this clinical entity.

Main Methods:

  • Systematic literature review of English-language publications on typhlitis.
  • Analysis of data from clinical series and case reports.

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Main Results:

  • Typhlitis is a spectrum of diseases, not a single entity.
  • Hallmark symptoms include right lower quadrant pain in an immunocompromised host with compromised mucosal integrity.

Conclusions:

  • Suspect typhlitis in immunocompromised patients with right lower quadrant pain and suggestive imaging.
  • Initial treatment involves intravenous fluids and antibiotics; surgical intervention is reserved for complications.