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Phosphaturic mesenchymal tumor-induced rickets.
M Reyes-Múgica1, S L Arnsmeier, P F Backeljauw
1Department of Pathology, Yale University School of Medicine, 310 Cedar Street, New Haven, CT 06520, USA.
Summary
Oncogenic rickets in children can be caused by rare tumors. Surgical removal of these phosphaturic mesenchymal tumors led to the resolution of rickets and hypophosphatemia.
Area of Science:
- Pediatric Endocrinology
- Oncology
- Radiology
Background:
- Oncogenic rickets is a rare condition characterized by renal phosphate wasting caused by tumors.
- This condition typically presents with bone pain, muscle weakness, and growth failure in children.
Observation:
- Two prepubertal girls presented with symptoms of rickets, including hypophosphatemia and hyperphosphaturia.
- Imaging revealed tumors: a mixed connective tissue variant in one and a nonossifying fibroma-like variant in the other.
Findings:
- Histological examination confirmed phosphaturic mesenchymal tumors in both patients.
- Tumor resection resulted in rapid correction of phosphate levels and healing of rickets.
Implications:
- Early detection and surgical removal of these tumors are crucial for treating oncogenic rickets.
- A thorough search for occult tumors is recommended in children with acquired phosphaturic rickets.