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Angiosarcoma arising in a bone infarct.

L A Cerilli¹, R E Fechner

¹Department of Pathology, The University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA.

Annals of Diagnostic Pathology

|December 14, 1999

Summary

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A rare angiosarcoma developed in a bone infarct in a 74-year-old man, the oldest reported case. Despite surgical removal, the patient developed fatal pulmonary metastases.

Area of Science:

Oncology
Pathology
Vascular Biology

Background:

Bone infarcts are rare, avascular bone necrosis sites.
Primary angiosarcomas are aggressive vascular tumors.
The association between bone infarcts and angiosarcoma is exceptionally uncommon.

Observation:

A 74-year-old male presented with a primary angiosarcoma of the femur.
The tumor was found in direct continuity with a pre-existing bone infarct.
Histopathological examination revealed pleomorphic cells with vasoformative features.

Findings:

Immunohistochemical markers (CD31, CD34, factor VIII-related antigen, Ulex europeus) confirmed endothelial differentiation.
The angiosarcoma was surgically resected via amputation.

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The patient developed pulmonary metastases post-surgery.

Implications:

This case represents the oldest documented patient with angiosarcoma linked to a bone infarct.
Highlights the potential for malignant transformation in bone infarcts.
Underscores the aggressive nature and metastatic potential of angiosarcomas, even in older individuals.