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Mechanical property predictions for polymorphs of sulphathiazole and carbamazepine
R J Roberts1, R S Payne, R C Rowe
1ZENECA Pharmaceuticals, Silk Road Business Park, Charter Way, Macclesfield, Cheshire, UK. ron.roberts@alderley.zaneca.com
Abstract:
The mechanical properties of polymorphs of sulphathiazole and carbamazepine have been determined experimentally by three-point beam bending. It is shown that the mechanical properties of sulphathiazole and carbamazepine polymorphs can be predicted using the atom-atom potential model applied to lattice dynamics, as long as account is taken of crystal morphology when considering the experimental results.