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Spectrophotometric methods for determining meloxicam in pharmaceuticals using batch and flow-injection procedures
M S García1, C Sánchez-Pedreño, M I Albero
1Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia, 30071-Murcia, Spain.
Summary
Two spectrophotometric methods were developed for sensitive and rapid meloxicam (MX) determination. These methods utilize the formation of a green complex with Fe(III) and are effective for pharmaceutical analysis.
Area of Science:
- Analytical Chemistry
- Pharmaceutical Analysis
Background:
- Meloxicam (MX) is a widely used nonsteroidal anti-inflammatory drug (NSAID).
- Accurate and efficient methods for MX quantification in pharmaceutical formulations are essential.
Purpose of the Study:
- To develop and validate two sensitive and rapid spectrophotometric methods for meloxicam determination.
- To apply these methods for routine analysis of meloxicam in pharmaceutical products.
Main Methods:
- Development of batch and flow-injection spectrophotometric procedures.
- Complexation reaction of meloxicam with Fe(III) in a methanolic medium.
- Spectrophotometric measurement of absorbance at 570 nm for batch methods and 362 nm for flow-injection method.
Main Results:
- Batch methods showed linearity from 2.0-200 and 5.00-250 mg l(-1) with detection limits of 0.47 and 0.72 mg l(-1).
- Flow-injection method demonstrated linearity from 0.5-20 mg l(-1) with a detection limit of 0.04 mg l(-1).
- Both methods proved effective for routine analysis of meloxicam in pharmaceutical samples.
Conclusions:
- The proposed spectrophotometric methods are sensitive, fast, and suitable for the routine determination of meloxicam in pharmaceuticals.
- The flow-injection method offers enhanced sensitivity and a lower detection limit.