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Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays
Published on: January 7, 2016
Quantitative growth hormone secretion and final adult height
P J Trainer1, M Palermo, J M Kirk
1Department of Endocrinology, St. Bartholomew's Hospital, London, UK. peter.trainer@man.ac.uk
Clinical Endocrinology
|December 14, 1999
Summary
Quantitative growth hormone (GH) secretion does not significantly impact final adult height in healthy individuals. This study found no differences in GH secretion between tall and short men, suggesting other factors determine final stature.
Area of Science:
- Endocrinology
- Human Growth and Development
- Metabolic Research
Background:
- The relationship between growth hormone (GH) secretion, height, growth velocity, and puberty is complex.
- Previous studies extensively investigated this relationship in children.
- This study aimed to clarify the role of quantitative GH secretion in determining final adult height.
Purpose of the Study:
- To investigate the relationship between quantitative GH secretion and final height in postpubertal men.
- To compare GH secretion dynamics in individuals with significantly different adult heights.
Main Methods:
- Studied 20 tall (>183 cm) and 20 short (<166 cm) postpubertal men (18-27 years).
- Assessed GH secretion via insulin-induced hypoglycemia, GHRH stimulation (with/without pyridostigmine), and spontaneous nocturnal secretion.
- Measured GH levels using IRMA and analyzed peak response, area under the curve (AUC), and pulse characteristics.
Main Results:
- No significant differences in GH response to hypoglycemia or GHRH were observed between tall and short groups.
- Spontaneous nocturnal GH secretion (pulse number, length, amplitude, AUC) did not differ between groups.
- Serum IGF-I levels were comparable in both tall and short individuals.
Conclusions:
- Quantitative GH secretion is not a significant determinant of final height in healthy adults.
- These findings suggest that other factors, not measured in this study, play a more crucial role in determining final stature.
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