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Related Experiment Videos

Barrier formation in the human fetus is patterned.

M J Hardman1, L Moore, M W Ferguson

  • 1School of Biological Sciences, University of Manchester, UK.

The Journal of Investigative Dermatology
|December 14, 1999
PubMed
Summary

Human infants develop a patterned skin barrier in utero, beginning around 20-24 weeks gestational age. This finding reveals early skin maturation and barrier formation in preterm infants, coinciding with their viability limits.

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Area of Science:

  • Developmental biology
  • Human physiology
  • Dermatology

Background:

  • Patterned stratum corneum maturation and skin barrier formation were previously observed in fetal rodents and rabbits.
  • Mammalian studies suggested the potential for similar patterned barrier development in human infants.

Purpose of the Study:

  • To investigate patterned stratum corneum development and skin barrier formation in preterm human infants.
  • To explore the relationship between periderm disaggregation and skin barrier formation in humans.

Main Methods:

  • Analysis of skin samples from preterm human infants at various gestational ages.
  • Utilized a mouse model to study the correlation between periderm disaggregation and barrier formation patterns.

Main Results:

Related Experiment Videos

  • Demonstrated patterned stratum corneum development and skin barrier formation in preterm human infants.
  • Initiation of human skin barrier formation observed regionally as early as 20-24 weeks gestational age.
  • Periderm disaggregation patterns were found to mirror and follow skin barrier formation patterns.

Conclusions:

  • Reveals regional patterning in skin maturation and barrier formation during human fetal development.
  • Human skin barrier formation in utero begins around the lower limit of preterm infant viability.
  • Suggests a relationship between periderm disaggregation and the initiation of skin barrier formation.