Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Renal basement membrane components.

J H Miner1

  • 1Department of Medicine, Renal Division, Washington University School of Medicine, St.Louis, MO 63110, USA. minerj@thalamus.wustl.edu

Kidney International
|December 14, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Role of fatty acid transport protein 4 in oleic acid-induced glucagon-like peptide-1 secretion from murine intestinal L cells.

American journal of physiology. Endocrinology and metabolism·2012
Same author

Type I collagen glomerulopathy: postnatal collagen deposition follows glomerular maturation.

Kidney international·2007
Same author

Choosing a mouse model to study the molecular pathobiology of Alport glomerulonephritis.

Kidney international·2007
Same author

CD2AP localizes to the slit diaphragm and binds to nephrin via a novel C-terminal domain.

The American journal of pathology·2001
Same author

The laminins in the murine inner ear: developmental transitions and expression in cochlear basement membranes.

Hearing research·2001
Same author

Localization of Lutheran, a novel laminin receptor, in normal, knockout, and transgenic mice suggests an interaction with laminin alpha5 in vivo.

Developmental dynamics : an official publication of the American Association of Anatomists·2001

Renal basement membranes are crucial for kidney function, composed of key proteins like laminin and collagen IV. Defects in these components can lead to kidney disease, highlighting their importance.

Area of Science:

  • Nephrology
  • Cell Biology
  • Biochemistry

Background:

  • Basement membranes are essential extracellular matrices surrounding cells, playing critical roles in kidney structure and function.
  • Defects in renal basement membranes are linked to kidney malfunction, underscoring their importance in renal health.
  • The major components include laminin, collagen IV, entactin/nidogen, and sulfated proteoglycans, which assemble to form the basement membrane.

Purpose of the Study:

  • To describe the major components of renal basement membranes.
  • To detail the localization of these components in developing and mature kidney basement membranes.
  • To discuss the impact of genetic mutations and aberrant protein deposition in renal diseases.

Main Methods:

  • Review of existing literature on basement membrane components.

Related Experiment Videos

  • Analysis of protein localization studies in renal tissues.
  • Examination of phenotypes associated with genetic mutations and disease states.

    • Main Results:

    • Identification and description of major renal basement membrane proteins: laminin, collagen IV, entactin/nidogen, and sulfated proteoglycans.
    • Elucidation of the localization patterns of these components during kidney development and in mature kidneys.
    • Correlation of basement membrane component defects with various kidney diseases and associated phenotypes.

    Conclusions:

    • Renal basement membrane composition and organization are vital for normal kidney function.
    • Understanding these components and their alterations is crucial for diagnosing and potentially treating renal diseases.
    • Ongoing research continues to uncover new components and their roles in renal health and disease.