Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Drug-resistant and multidrug-resistant tubercle bacilli.

B Petrini1, S Hoffner

  • 1Department of Clinical Microbiology, Karolinska Institute and Hospital, Stockholm, Sweden. bjornp@mb.ks.se

International Journal of Antimicrobial Agents
|December 14, 1999
PubMed
Summary

Multidrug-resistant tuberculosis (MDR-TB) emerged due to human activity and inadequate drug use. Effective surveillance is crucial as MDR-TB strains spread globally, posing a significant international health challenge.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Protecting Pyrazinamide, a Priority for Improving Outcomes in Multidrug-Resistant Tuberculosis Treatment.

Antimicrobial agents and chemotherapy·2017
Same author

Molecular Epidemiology of Mycobacterium Tuberculosis Strains in the North-West and West of Iran.

Annals of medical and health sciences research·2015
Same author

Patients with lymphatic malformations who receive the immunostimulant OK-432 experience excellent long-term outcomes.

Acta paediatrica (Oslo, Norway : 1992)·2015
Same author

Revisiting susceptibility testing in MDR-TB by a standardized quantitative phenotypic assessment in a European multicentre study.

The Journal of antimicrobial chemotherapy·2015
Same author

Evaluation of a biphasic media assay for pyrazinamide drug susceptibility testing of Mycobacterium tuberculosis.

The Journal of antimicrobial chemotherapy·2014
Same author

Proficiency of drug susceptibility testing of Mycobacterium tuberculosis against pyrazinamide: the Swedish experience.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2013

Area of Science:

  • Microbiology
  • Epidemiology
  • Public Health

Background:

  • Drug-resistant (DR) and multidrug-resistant (MDR) tuberculosis (TB) are human-induced phenomena, emerging after the introduction of chemotherapeutic agents.
  • Inadequate drug regimens, including monotherapy, have significantly contributed to the development and spread of MDR-TB strains.
  • MDR-TB is disproportionately prevalent in areas with weak national TB programs and poor socioeconomic conditions, and can spread through communities like prisons.

Purpose of the Study:

  • To review key aspects of drug resistance in tuberculosis.
  • To discuss the epidemiology, diagnosis, and resistance mechanisms of TB.
  • To highlight the growing international significance of MDR-TB.

Main Methods:

  • This is a review article, synthesizing existing knowledge on DR-TB.

Related Experiment Videos

  • The review discusses epidemiological data, diagnostic approaches, and molecular mechanisms of resistance.
  • Information is drawn from existing literature on tuberculosis resistance patterns.

    • Main Results:

    • Drug resistance in TB is a direct consequence of human intervention, particularly the use of antimicrobial drugs.
    • Factors such as incomplete treatment, poor drug quality, and weak healthcare systems facilitate the emergence and spread of MDR-TB.
    • Global travel facilitates the international dissemination of resistant TB strains, complicating control efforts.

    Conclusions:

    • MDR-TB represents a critical global health threat requiring international attention and robust surveillance.
    • Effective surveillance of TB resistance patterns is essential in all countries to combat the spread of resistant strains.
    • Addressing socioeconomic factors and strengthening national TB programs are vital for controlling MDR-TB.