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Published on: July 9, 2012
The MYSTIC (meropenem yearly susceptibility test information collection) programme
P J Turner1, J M Greenhalgh, J R Edwards
1Anti-Infectives Development and Technical Support Group, Cancer and Infection Research Department, AstraZeneca, Macclesfield, Cheshire, UK. philip.turner@astrazeneca.com
International Journal of Antimicrobial Agents
|December 14, 1999
Summary
The MYSTIC study monitored meropenem
Area of Science:
- Clinical Microbiology
- Infectious Diseases
- Pharmacology
Background:
- Antibiotic resistance is a growing global health concern.
- Meropenem is a broad-spectrum carbapenem antibiotic used for serious infections.
- Monitoring antibiotic performance is crucial for effective treatment strategies.
Purpose of the Study:
- To monitor the performance and spectrum of activity of meropenem.
- To establish hospital-specific antibiotic susceptibility profiles.
- To assess trends in bacterial resistance to meropenem and comparator antibiotics.
Main Methods:
- Prospective surveillance study over at least 3 years.
- Collection of bacterial isolates from patients with intra-abdominal infections (IAI) and/or lower respiratory tract infections (LRTI).
- Antimicrobial susceptibility testing against meropenem and comparator agents in specialist and non-specialist centers.
Main Results:
- Meropenem demonstrated retained broad-spectrum activity and potency in the first year of the study.
- Evidence of declining activity of comparator antibiotics due to resistance mechanisms was observed.
- Data collected from 33 centers across Europe, Israel, and Mexico.
Conclusions:
- Meropenem remains an effective therapeutic option.
- Ongoing monitoring is essential to track evolving resistance patterns.
- Hospital-specific data can inform local antibiotic stewardship programs.
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