Salmonella meningitis and multiple cerebral abscesses in an infant

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Chronic Salmonella Infected Mouse Model
09:01

Chronic Salmonella Infected Mouse Model

Published on: May 31, 2010

M R Workman1, E H Price, P Bullock

  • 1Department of Medical Microbiology, King's College School of Medicine and Dentistry, London, UK.

International Journal of Antimicrobial Agents
|December 14, 1999
PubMed

Insights

A Salmonella enteritidis infection caused meningitis and brain abscesses in an infant. Successful treatment involved antibiotics, surgery, and immunoglobulin therapy without joint toxicity.

Area of Science:

  • Pediatric Infectious Diseases
  • Neuroscience
  • Microbiology

Background:

  • Salmonella enteritidis is a common cause of bacterial gastroenteritis.
  • Invasive Salmonella infections can lead to severe complications, including meningitis and brain abscesses, particularly in neonates and infants.
  • Cerebral abscesses in infants present significant management challenges due to potential neurological sequelae.

Observation:

  • A 4-week-old infant presented with meningitis and multiple cerebral abscesses.
  • The causative agent was identified as Salmonella enteritidis.
  • The infant underwent a complex treatment regimen.

Findings:

  • Successful management was achieved with a prolonged course of antibiotics, notably ciprofloxacin.
  • Neurosurgical drainage of the cerebral abscesses was a critical component of treatment.
  • Long-term immunoglobulin supplements were administered.
  • No adverse effects, specifically joint toxicity, were observed during or after treatment.

Implications:

  • This case highlights the successful multimodal treatment approach for invasive Salmonella enteritidis infections in infants.
  • The findings suggest that aggressive management including antibiotics, surgical intervention, and supportive therapies can lead to favorable outcomes.
  • The absence of joint toxicity with ciprofloxacin in this context warrants further investigation in pediatric populations.

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