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Updated: Sep 12, 2026
A New Murine Model of Endovascular Aortic Aneurysm Repair
Published on: July 7, 2013
Postoperative downregulation of MHC class II antigen on monocytes does not differ between open and endovascular
I Syk1, A Andreasson, L Truedsson
1Department of Surgery, Malmö University Hospital, Sweden.
Objectives:
To study immune cell response and histocompability class II (HLA-DR) expression after aortic aneurysm repair.
Setting:
University hospital, Sweden.
Subjects:
42 patients operated on for aortic aneurysm, 26 by an endovascular and 16 by an open technique.
Main Outcome Measures:
Analysis of HLA-DR expression and concentrations of blood mononuclear cells by flow cytometry. Splanchnic pH analysed by tonometry and interleukin-6 and tumour necrosis factor-alpha measured by enzyme-linked immunosorbent assay.
Results:
The HLA-DR expression on lymphocytes did not change, whereas total HLA-DR expression on monocytes was downregulated, and more pronounced in five patients who developed severe postoperative complications. There were no differences in cell or HLA-DR responses between the two operations.
Conclusions:
Both endovascular and open repair of aortic aneurysm produced similar downregulation of monocyte HLA-DR expression and similar responses in circulating mononuclear blood cells. There was pronounced downregulation of monocyte HLA-DR expression in patients with severe postoperative complications.
