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Related Experiment Videos

The C-reactive protein.

B Clyne1, J S Olshaker

  • 1Department of Surgery, University of Maryland Medical System, Baltimore 21201, USA.

The Journal of Emergency Medicine
|December 14, 1999
PubMed
Summary
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C-reactive protein (CRP) is an acute phase protein useful for monitoring inflammation. However, its utility in the emergency department is limited, and it should not delay antibiotic treatment for serious infections.

Area of Science:

  • Biochemistry
  • Clinical Medicine
  • Immunology

Background:

  • C-reactive protein (CRP) identified in 1930 as an acute phase protein.
  • CRP historically used as an inflammation screening device and disease activity marker.
  • Advancements in CRP quantification have expanded its clinical applications.

Purpose of the Study:

  • To evaluate the utility of C-reactive protein (CRP) in the emergency department (ED).
  • To determine the diagnostic and prognostic value of CRP in various acute conditions.
  • To assess the role of CRP as an adjunct in specific clinical scenarios.

Main Methods:

  • Review of existing literature and clinical applications of CRP.
  • Analysis of CRP levels in various infectious and inflammatory conditions.

Related Experiment Videos

  • Interpretation of CRP in the context of clinical presentation and other diagnostic tools.

    • Main Results:

    • CRP has limited utility for ruling in or out diagnoses in the ED.
    • CRP may aid in diagnosing appendicitis adjunctively in CT-absent settings.
    • Elevated CRP can indicate complications or treatment failure in pneumonia, pancreatitis, PID, and UTIs.
    • CRP is typically elevated in meningitis, neonatal sepsis, and occult bacteremia, but not diagnostic.

    Conclusions:

    • CRP has limited diagnostic utility in the emergency department.
    • CRP can be a useful adjunct in specific situations like equivocal appendicitis.
    • CRP elevation may signal complications but should not replace clinical judgment or timely antibiotic administration.