Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Treating multiple-risk hypertensive populations.

S Oparil1

  • 1Vascular Biology and Hypertension Program, University of Alabama-Birmingham, 35294, USA. soparil@uab.edu

American Journal of Hypertension
|December 22, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intensive Blood Pressure Management Preserves Functional Connectivity in Patients with Hypertension from the Systolic Blood Pressure Intervention Randomized Trial.

AJNR. American journal of neuroradiology·2023
Same author

Lowering Albuminuria-Does It Lower the Cardiovascular Risk?: Reduction in Albuminuria Translates to Reduction in Cardiovascular Events in Hypertensive Patients: Losartan Intervention for Endpoint Reduction in Hypertension Study. Hypertension 45: 198-202, 2005.

Journal of the American Society of Nephrology : JASN·2023
Same author

Reducing Microalbuminuria-Does It Lower Cardiovascular Risk?: Reduction in Albuminuria Translates to Reduction in Cardiovascular Events in Hypertensive Patients: Losartan Intervention for Endpoint Reduction in Hypertension Study. Hypertension 45: 198-202, 2005.

Journal of the American Society of Nephrology : JASN·2023
Same author

Effect of spironolactone on diastolic function in hypertensive left ventricular hypertrophy.

Journal of human hypertension·2014
Same author

Relationships between metrics of visit-to-visit variability of blood pressure.

Journal of human hypertension·2013
Same author

Long-term effects of aldosterone blockade in resistant hypertension associated with chronic kidney disease.

Journal of human hypertension·2011
Same journal

Hemodynamic Evolution of Heart Failure from Hypertension: Lower Stroke Volume Index and Higher Heart Rate.

American journal of hypertension·2026
Same journal

Opposite Seasonal Variation in Nighttime and Morning Blood Pressure: A Longitudinal Study of Patients with Hypertension.

American journal of hypertension·2026
Same journal

Screening for Postprandial Hypotension: The Importance of Home Blood Pressure Monitoring.

American journal of hypertension·2026
Same journal

Distinct Mediating Roles of Hypertension in Arterial Stiffness Mechanisms Associated with Cardiovascular Disease Risk: A Community-Based Cohort Study.

American journal of hypertension·2026
Same journal

Long-term systolic blood pressure time in target and risk of cardiovascular events in older adults: a secondary analysis of the ASPREE cohort.

American journal of hypertension·2026
Same journal

Estimated Pulse Wave Velocity Predicts Outcomes After Acute Ischemic Stroke: A Multinational Cohort Analysis.

American journal of hypertension·2026
See all related articles

Aggressively controlling high blood pressure (hypertension) in patients with multiple risk factors, including the elderly and those with diabetes, significantly reduces cardiovascular and renal disease risks. Lowering blood pressure is crucial for preventing serious health complications.

Area of Science:

  • Cardiology
  • Nephrology
  • Geriatrics
  • Endocrinology

Background:

  • Most hypertension patients have additional cardiovascular disease risk factors.
  • Identifying and stratifying risk in hypertensive patients is crucial for treatment planning.
  • Elderly patients, those with diabetes, and individuals with target-organ damage are at higher risk.

Purpose of the Study:

  • To highlight the importance of risk stratification in hypertension management.
  • To emphasize the benefits of aggressive blood pressure control in high-risk populations.
  • To underscore the need for lower blood pressure goals in specific patient groups.

Main Methods:

  • Review of evidence supporting increased risk in elderly, diabetic, and renal-impaired hypertensive patients.

Related Experiment Videos

  • Analysis of clinical trial results demonstrating benefits of aggressive blood pressure control.
  • Examination of trends in hypertension, aging, diabetes, and end-stage renal disease.

    • Main Results:

    • Isolated systolic hypertension (ISH) is prevalent in the elderly and associated with significant morbidity/mortality.
    • Type 2 diabetes increases risk for coronary heart disease, stroke, and renal failure.
    • Aggressive blood pressure control dramatically decreases cardiovascular complications in diabetic patients.
    • Poorly controlled hypertension is a major contributor to increased end-stage renal disease.
    • Lowering blood pressure below traditional goals is necessary to slow renal dysfunction.

    Conclusions:

    • Aggressive hypertension management in multiple-risk populations significantly reduces stroke, heart failure, coronary heart disease, and renal failure.
    • Lowering blood pressure to recommended goals (e.g., JNC VI, WHO-ISH) is essential for preventing cardiovascular and renal complications.
    • Hypertension treatment should be tailored to individual risk factors, especially in the elderly and diabetic populations.