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Cardiopulmonary bypass increases plasma bradykinin concentrations
M Cugno1, J Nussberger, P Biglioli
1Department of Internal Medicine, IRCCS Maggiore Hospital, University of Milan, Italy.
Immunopharmacology
|December 22, 1999
Summary
Bradykinin (BK) levels rise during cardiopulmonary bypass (CPB) due to reduced breakdown. This suggests impaired BK metabolism in extracorporeal circulation contributes to its increase.
Area of Science:
- Biochemistry
- Physiology
- Cardiovascular Surgery
Background:
- Cardiopulmonary bypass (CPB) involves complex physiological changes.
- Bradykinin (BK) is a peptide involved in vascular and inflammatory responses.
- Elevated BK levels have been noted during CPB procedures.
Purpose of the Study:
- To investigate the changes in bradykinin (BK) plasma levels during cardiopulmonary bypass (CPB).
- To explore the potential contribution of reduced BK catabolism to its observed increase during CPB.
Main Methods:
- Observation of bradykinin (BK) plasma levels.
- Monitoring of coagulation cascade, fibrinolysis, complement, and cytokine activation during CPB.
- Extracorporeal circulation procedure was employed, excluding lung function.
Main Results:
- Increased bradykinin (BK) plasma levels were observed during CPB.
- Activation of the coagulation cascade, fibrinolysis, complement, and cytokines occurred concurrently.
- The lungs, a primary site for BK breakdown, were excluded during extracorporeal circulation.
Conclusions:
- Reduced catabolism of bradykinin (BK) is a likely factor contributing to its elevated levels during CPB.
- Impaired BK metabolism during extracorporeal circulation warrants further investigation.
- Understanding BK dynamics during CPB may inform clinical management.