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Binding affinity of GM3 lactone for influenza virus
1Department of Biomolecular Engineering, Tokyo Institute of Technology, Yokohama, Japan. tsato@bio.titech.ac.jp
Glycoconjugate Journal
|December 22, 1999
Abstract:
We investigated the interaction of GM3 lactone with influenza virus. The specific bindings of influenza virus and its hemagglutinin to GM3 lactone-containing mixed monolayers were studied by using a quartz-crystal microbalance. It has been known that gangliosides as receptors for influenza virus are also substrates for virus neuraminidase. GM3 lactone, however, was found to bind to influenza virus hemagglutinin, but not to be substrate for virus neuraminidase.