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Pantoprazole suppresses Helicobacter pylori without affecting cure
R J Adamek1, C Szymanski, B Pfaffenbach
1Department of Medicine, St. Josef-Hospital, Ruhr-University, Bochum, Germany.
Helicobacter
|December 22, 1999
Summary
Pretreating with pantoprazole before standard triple therapy effectively eradicates Helicobacter pylori. This approach does not negatively impact the success rates of the subsequent H. pylori cure regimen.
Area of Science:
- Gastroenterology
- Microbiology
- Pharmacology
Background:
- Standard short-term, low-dose triple therapy (proton-pump inhibitor + 2 antibiotics) is the gold standard for Helicobacter pylori eradication.
- The impact of proton-pump inhibitor pretreatment on eradication outcomes remains uninvestigated.
Purpose of the Study:
- To assess the influence of pantoprazole pretreatment on the efficacy of a subsequent triple therapy for H. pylori eradication.
Main Methods:
- A randomized, parallel-group study involving 107 patients with duodenal ulcer or functional dyspepsia.
- Patients received a 7-day triple therapy (pantoprazole, clarithromycin, metronidazole) either preceded (P-PCM) or followed (PCM-P) by 7-day pantoprazole pretreatment.
- H. pylori status was confirmed using urease breath tests and biopsy urease tests.
Main Results:
- Pantoprazole pretreatment significantly reduced delta values in the 13C urea breath test, indicating H. pylori suppression.
- H. pylori eradication rates were high: 90% in the P-PCM group (47/52) and 87% in the PCM-P group (46/53).
Conclusions:
- Pretreatment with pantoprazole effectively suppresses H. pylori.
- This pretreatment does not compromise the efficacy of a consecutive short-term, low-dose triple therapy for H. pylori eradication.