Related Experiment Video
Updated: Oct 18, 2026

In Vivo Modeling of the Morbid Human Genome using Danio rerio
Published on: August 24, 2013
Detection and modeling of disease susceptibility locus effects: how much can be learned from contrast of populations?
E Génin1, F Guyon, P Margaritte-Jeannin
1HEXAGEN, Cambridge, UK.
Abstract:
We report the results of our analyses of the GAW11 Problem 2 data set, using information from three different populations. In the first part of the paper, we used classical population genetic tests to compare affected individuals from the different populations, stratifying on the environmental factors. Thanks to existing linkage disequilibrium in one population, we found one of the disease susceptibility loci. In the second part of the paper, we used the marker association segregation chi 2 method to model the role of this disease susceptibility locus in the different populations and draw some inferences regarding the model used at that locus to generate the data.
Related Concept Videos
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Genetic Lingo
Pharmacogenomics: Identification of New Drug Targets