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Environmental covariates: effects on the power of sib-pair linkage methods
D M Mandal1, A J Sorant, E W Pugh
1Department of Medicine, Louisiana State University Medical Center, New Orleans, USA.
Genetic Epidemiology
|December 22, 1999
Abstract:
The effect of inclusion of environmental risk factors on the power of sib-pair linkage methods was tested for a qualitative trait. It was found that inclusion of an environmental variable did not increase the power of the Haseman-Elston (H-E) sib-pair nonparametric linkage analysis test. However, a significant increase in power was observed for both the H-E and affected-sib-pair tests, even in small samples, when persons unexposed to the environmental risk factor were coded as unknown.