A method for meta-analysis of genome searches: application to simulated data
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Updated: Oct 18, 2026

Pattern-based Search of Epigenomic Data Using GeNemo
Published on: October 8, 2017
1Division of Medical and Molecular Genetics, Guy's, King's and St. Thomas' School of Medicine, King's College London, UK.
Abstract:
Genome searches have been performed for many complex traits, and in some cases several searches have been performed in a single disease. Replication of significant results is rare, and a systematic method of reviewing results from a number of searches is needed. A method for meta-analysis is presented which provides a systematic descriptive overview of the separate analyses while dealing with some of the problems specific to meta-analysis of genome searches. The results of two separate meta-analyses correctly indicate the presence of susceptibility loci on chromosomes 1, 3, and 5 in the GAW11 Problem 2 data.
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