Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Candida arthritis treated with amphotericin B.

D G Poplack, S A Jacobs

    The Journal of Pediatrics
    |December 1, 1975
    PubMed
    Summary

    A patient with acute lymphoblastic leukemia experienced knee arthritis due to Candida tropicalis. Intra-articular amphotericin B injections, alongside systemic therapy, successfully resolved the fungal knee infection.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Summertime methane and carbon dioxide emission rates and associated variables from a national-scale survey of 146 reservoirs in the United States.

    Limnology and oceanography letters·2026
    Same author

    Is Neuroradiology Complementary to Histopathology in Central Nervous System Tumors with an Alteration of the BCOR Gene?

    Clinical neuroradiology·2023
    Same author

    A flexible proton beam imaging energy spectrometer (PROBIES) for high repetition rate or single-shot high energy density (HED) experiments (invited).

    The Review of scientific instruments·2023
    Same author

    Capacity building: a novel pediatric hematology-oncology fellowship program in sub-Saharan Africa.

    Blood advances·2018
    Same author

    Weekly paclitaxel and concurrent pazopanib following doxorubicin and cyclophosphamide as neoadjuvant therapy for HER-negative locally advanced breast cancer: NSABP Foundation FB-6, a phase II study.

    Breast cancer research and treatment·2014
    Same author

    Overexpression of the NR2A subunit in the forebrain impairs long-term social recognition and non-social olfactory memory.

    Genes, brain, and behavior·2014

    Area of Science:

    • Mycology
    • Rheumatology
    • Infectious Diseases

    Background:

    • Acute lymphoblastic leukemia (ALL) is an aggressive blood cancer.
    • Fungal infections, particularly Candida species, can complicate leukemia treatment.
    • Septic arthritis is a serious joint infection requiring prompt management.

    Observation:

    • A case of knee arthritis caused by Candida tropicalis in an acute lymphoblastic leukemia patient is presented.
    • Initial systemic amphotericin B therapy partially controlled the infection but did not achieve resolution.
    • The patient's arthritis symptoms persisted despite systemic antifungal treatment.

    Findings:

    • Complete resolution of Candida tropicalis knee arthritis was achieved after three intra-articular injections of amphotericin B.
    • This suggests that localized administration of antifungals can be effective in refractory cases.
    • The combination of systemic and intra-articular therapy proved crucial for treatment success.

    Implications:

    • Intra-articular amphotericin B may be a valuable adjunctive therapy for fungal arthritis, especially in immunocompromised patients.
    • This approach could offer a targeted treatment option for localized fungal joint infections.
    • Further research into localized antifungal delivery methods for complex infections is warranted.

    Related Experiment Videos