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Involvement of serotonin in zimelidine-induced hyperglycemia in mice
Y Sugimoto1, K Inoue, J Yamada
1Department of Pharmacology, Kobe Pharmaceutical University, Japan.
Biological & Pharmaceutical Bulletin
|December 22, 1999
Abstract:
Effects of a selective serotonin reuptake inhibitor, zimelidine, on plasma glucose was studied in mice. Zimelidine dose-dependently induced hyperglycemia, although it did not change insulin levels. To determine the involvement of the serotonergic system in zimelidine-induced hyperglycemia, effects of the 5-HT depleter p-chlorophenylalanine(pCPA) were examined. pCPA significantly reduced zimelidine-induced hyperglycemia. This suggests that zimelidine-induced hyperglycemia is mediated by the serotonergic system through its 5-HT reuptake inhibition.