[Restenosis after angioplasty]

Restenosis remains the main limitation of endocoronary methods of revascularisation. It is observed in 20 to over 50% of cases, depending on the prevailing risk factors and techniques used. The mechanism of post balloon angioplasty restenosis consists of neointimal hyperplasia, vascular remodelling and thrombosis. Intra-stent thrombosis is mainly caused by the neointimal hyperplasia. The strategies developed to prevent restenosis may be grouped in two categories: mechanical and pharmacological strategies. Stenting is the only mechanical method to have been shown to be effective. With respect to pharmacological methods, the general impression is rather negative even if some positive results have been reported recently. Of the new strategies which may provide a solution in the coming years, gene therapy and endocoronary irradiation justify a special mention.