Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Multiple sclerosis: one or several diseases?].

J J Hauw1, C Lubetzki, A Tourbah

  • 1Laboratoire de Neuropathologie Escourolle (INSERM U. 104 et 360, association Claude-Bernard).

La Revue Du Praticien
|December 22, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Positive effect of evobrutinib in CNS remyelination models and lack of synergy with clemastine-A dose response study.

Multiple sclerosis journal - experimental, translational and clinical·2025
Same author

Deleterious functional consequences of perfluoroalkyl substances accumulation into the myelin sheath.

Environment international·2023
Same author

A randomized double-blind placebo-controlled trial of low-dose interleukin-2 in relapsing-remitting multiple sclerosis.

Journal of neurology·2023
Same author

Secondary progressive multiple sclerosis: A national consensus paper on diagnostic criteria.

Revue neurologique·2022
Same author

Health related quality of life and perceived social support in French and Lebanese MS patients: A comparative study.

Multiple sclerosis and related disorders·2022
Same author

Microglia-neuron interaction at nodes of Ranvier depends on neuronal activity through potassium release and contributes to remyelination.

Nature communications·2021
Same journal

[Prolonged fever].

La Revue du praticien·2026
Same journal

[Lower gastrointestinal bleeding].

La Revue du praticien·2026
Same journal

[Management of antiplatelet agents and oral anticoagulants in cases of gastrointestinal bleeding].

La Revue du praticien·2026
Same journal

[A history of child abuse intervention in the West].

La Revue du praticien·2026
Same journal

[Agranulocytose médicamenteuse].

La Revue du praticien·2026
Same journal

[Patient education in heart failure].

La Revue du praticien·2026
See all related articles

Multiple sclerosis (MS) clinical courses may stem from varying lesion severity and distribution. This heterogeneity in nervous tissue response to injury could explain MS variants and guide diverse therapeutic strategies.

Area of Science:

  • Neuroimmunology
  • Neuropathology

Context:

  • Multiple sclerosis (MS) presents diverse clinical courses, including relapsing-remitting, primary progressive, secondary progressive, and progressive-relapsing forms.
  • These variants are hypothesized to correlate with differences in lesion characteristics such as inflammation, demyelination, axonal injury, and necrosis.

Purpose:

  • To explore the potential link between clinico-pathological heterogeneity in multiple sclerosis and distinct underlying disease mechanisms or nervous tissue responses.
  • To investigate whether variants of MS might represent different diseases or a variable reaction to an initial injury.

Summary:

  • The varied clinical presentations of MS are likely associated with differences in the severity and distribution of pathological lesions (inflammation, demyelination, axonal damage, necrosis).
  • While some MS variants share mechanisms with related neurological conditions, others may be distinct diseases.

Related Experiment Videos

  • The prevailing hypothesis posits that MS heterogeneity arises from variable nervous tissue vulnerability to an initial injury, influenced by unknown factors.

    • Impact:

    • Understanding the basis of MS heterogeneity can inform the development of tailored therapeutic approaches for different clinical courses.
    • Clarifying the relationship between MS variants and distinct disease mechanisms may refine diagnostic criteria and prognostic assessments.
    • This research highlights the need for further investigation into the factors influencing nervous system vulnerability in MS pathogenesis.