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Quantitative Polymerase Chain Reaction (qPCR)-Based Rapid Diagnosis of Helicobacter pylori Infection and Antibiotic Resistance
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H. pylori IgG antibodies in children

H Qureshi1, S Hafiz, I Medhi

  • 1PMRC Research Centre, Jinnah Postgraduate Medical Centre, Karachi.

JPMA. the Journal of the Pakistan Medical Association
|December 22, 1999
PubMed

Insights

Helicobacter pylori (H. pylori) IgG antibody exposure in healthy children increases with age and lower socioeconomic status. Early childhood H. pylori infection may be linked to feeding practices and adult dental plaque reservoirs.

Area of Science:

  • Pediatric infectious diseases
  • Gastroenterology
  • Microbiology

Background:

  • Helicobacter pylori (H. pylori) is a significant human pathogen.
  • Understanding H. pylori exposure in children is crucial for public health.
  • Prevalence varies globally, influenced by socioeconomic and environmental factors.

Purpose of the Study:

  • To determine the seroprevalence of H. pylori IgG antibodies in apparently healthy children.
  • To investigate the relationship between H. pylori exposure, age, and socioeconomic status in pediatric populations.

Main Methods:

  • Serum samples from 100 healthy children (6 months to 10 years) were analyzed for H. pylori IgG antibodies.
  • Children were categorized into two age groups: 6 months to <5 years and 5-10 years.
  • Abbott's flexpack kit was utilized for antibody detection.

Main Results:

  • Overall H. pylori exposure rate was 33% in the studied children.
  • Exposure rates increased with age, with higher prevalence in older children (5-10 years) at 40%.
  • Lower socioeconomic status was associated with significantly higher H. pylori exposure rates (42.1% in group I, 62.5% in group II).

Conclusions:

  • H. pylori exposure in children is positively correlated with increasing age and decreasing socioeconomic status.
  • Early childhood exposure may be linked to maternal feeding practices, such as the use of premasticated food.
  • Dental plaque in adults is identified as a potential reservoir for H. pylori transmission.
Abstract

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