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Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
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Testing the Role of Multicopy Plasmids in the Evolution of Antibiotic Resistance
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Antibiotic resistance in bacteria. A current and future problem.

H H Liu1

  • 1Allegheny University Medical Practices, Allegheny University of the Health Sciences, Cheltenham, Pennsylvania 19012, USA. liuliang@AOL.com

Advances in Experimental Medicine and Biology
|December 22, 1999
PubMed
Summary

Antibiotic resistance is a growing threat, leaving few treatment options for serious infections. This review covers resistant bacteria, diagnostics, and new therapies for dermatologic and rheumatologic conditions.

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Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

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Area of Science:

  • Microbiology
  • Infectious Diseases
  • Dermatology
  • Rheumatology

Background:

  • Increasing bacterial resistance to antibiotics limits therapeutic options.
  • Emergence of multidrug-resistant organisms poses significant clinical challenges.
  • Problematic pathogens include vancomycin-resistant staphylococci and enterococci, and multiply-resistant Gram-negative bacilli.

Purpose of the Study:

  • To discuss problem pathogens causing dermatologic and rheumatologic infections.
  • To review risk factors, diagnostic methods, and resistance mechanisms.
  • To examine geographic prevalence, spread, and prevention strategies for resistant bacteria.
  • To present information on novel antimicrobial agents and investigational therapies.

Main Methods:

  • Literature review and synthesis of current research on antibiotic resistance.
  • Analysis of epidemiological data on resistant pathogens.
  • Overview of diagnostic approaches for detecting resistant organisms.
  • Examination of emerging antimicrobial treatments.

Main Results:

  • Specific resistant pathogens like vancomycin-resistant staphylococci and multiply-resistant Gram-negative bacilli are highlighted.
  • Risk factors for acquiring these infections are identified.
  • Diagnostic studies for detection are reviewed.
  • Newer topical and systemic antimicrobial agents, including investigational therapies, are presented.

Conclusions:

  • Urgent need for effective strategies to combat rising antibiotic resistance.
  • Importance of understanding resistance mechanisms and spread.
  • Development and application of novel antimicrobial therapies are crucial.
  • Multifaceted approach required for prevention and control of resistant infections.