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Related Experiment Videos

Newer concepts in antimicrobial therapy.

L C Parish1

  • 1Department of Dermatology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Advances in Experimental Medicine and Biology
|December 22, 1999
PubMed
Summary
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Antimicrobial agents are crucial for treating bacterial infections and possess anti-inflammatory properties. Dermatologists utilize a diverse range of antibiotics, including newer agents and updated older ones, to manage various skin conditions effectively.

Area of Science:

  • Dermatology
  • Pharmacology
  • Infectious Diseases

Background:

  • Antimicrobial agents are vital in clinical practice for treating bacterial infections.
  • Beyond direct antibacterial action, they offer anti-inflammatory benefits and antagonism against superantigens.
  • The evolution of antimicrobial drugs includes new quinolones, macrolides, cephalosporins, and enhanced penicillins.

Purpose of the Study:

  • To review the significant role of antimicrobial agents in dermatologic practice.
  • To highlight the expanded therapeutic armamentarium available to dermatologists.
  • To discuss both the benefits and potential adverse effects of antimicrobial therapies in skin conditions.

Main Methods:

  • Review of current literature on antimicrobial agents in dermatology.

Related Experiment Videos

  • Analysis of the therapeutic applications of various antibiotic classes.
  • Examination of known and potential side effects associated with antimicrobial use.

    • Main Results:

    • Newer antimicrobial agents and updated older drugs offer dermatologists a versatile treatment arsenal.
    • Specific antimicrobials like clarithromycin show efficacy in treating acne vulgaris and acne rosacea.
    • Rifamycin is effective for treating leishmaniasis.
    • Potential adverse effects include phototoxicity (quinolones), bullous diseases (penicillins), vasculitis (quinolones), and porphyria (tetracyclines).

    Conclusions:

    • Antimicrobial therapy remains integral to managing numerous dermatitides, diminishing signs and symptoms.
    • Dermatologists must be aware of the broad spectrum of antimicrobial benefits and potential adverse effects.
    • The continuous development and repurposing of antimicrobials enhance dermatologic treatment options.