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Related Experiment Videos

Vasogenic edema on MELAS: a serial study with diffusion-weighted MR imaging.

M Yoneda1, M Maeda, H Kimura

  • 1Second Department of Internal Medicine, Fukui Medical University, Japan. myoneda@fmsrsa.fukui-med.ac.jp

Neurology
|December 22, 1999
PubMed
Summary

Diffusion-weighted MRI (DWI) reveals increased apparent diffusion coefficient in acute stroke-like lesions in patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like syndrome (MELAS), indicating vasogenic edema.

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Area of Science:

  • Neurology
  • Radiology
  • Genetics

Background:

  • Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like syndrome (MELAS) is a rare mitochondrial disease.
  • MELAS is characterized by stroke-like episodes, seizures, and lactic acidosis.
  • Neuroimaging is crucial for diagnosing and monitoring MELAS.

Observation:

  • A serial study was conducted on a patient diagnosed with MELAS.
  • The patient presented with acute stroke-like episodes.
  • Diffusion-weighted MRI (DWI) was utilized to assess the brain lesions.

Findings:

  • DWI revealed a higher apparent diffusion coefficient (ADC) in the acute stroke-like lesions compared to control regions.
  • Elevated ADC values suggest increased water diffusion within the affected brain tissue.

Related Experiment Videos

  • The findings indicate the presence of vasogenic edema during acute stroke-like episodes in MELAS.

    • Implications:

    • DWI can aid in the early detection and characterization of stroke-like lesions in MELAS.
    • Understanding the pathophysiological basis of these lesions can inform treatment strategies.
    • Further research into the role of vasogenic edema in MELAS pathogenesis is warranted.