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Related Experiment Videos

A transient geniculo-extrastriate pathway in macaques? Implications for 'blindsight'.

K M Sorenson1, H R Rodman

  • 1Department of Psychology, Yerkes Regional Primate Research Center, Emory University, Atlanta, GA 30322, USA.

Neuroreport
|December 22, 1999
PubMed
Summary

Infant monkeys with visual cortex damage show better vision recovery than adults. Unlike cats, infant primates lack a specific transient pathway from the dorsal lateral geniculate nucleus to visual areas, suggesting a different recovery mechanism.

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Area of Science:

  • Neuroscience
  • Visual System Development
  • Comparative Neurology

Background:

  • Early-life damage to the primary visual cortex (V1) in animals results in better vision recovery compared to adult-onset damage.
  • In cats, this enhanced recovery is partly attributed to a transient pathway from the dorsal lateral geniculate nucleus (dLGN) to visual area PMLS.

Purpose of the Study:

  • To investigate if a similar transient dLGN pathway to dorsal extrastriate areas exists in infant primates.
  • To determine if such a pathway could be recruited for vision recovery after early V1 lesions in primates.

Main Methods:

  • Retrograde tracers were injected into areas MT, MST, and/or 7a in infant macaques.
  • The study examined projections from the dLGN to these dorsal extrastriate visual areas.

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Main Results:

  • No evidence of a transient pathway from the dLGN to the targeted dorsal extrastriate areas (MT, MST, 7a) was found in infant macaques.
  • Projections from the pulvinar and other extrastriate areas to these regions were observed.

Conclusions:

  • Infant primates do not appear to utilize a transient dLGN pathway to dorsal extrastriate areas for vision recovery after early V1 damage.
  • Alternative mechanisms, potentially involving projections from the pulvinar or other extrastriate areas, may underlie the observed recovery in primates.