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Updated: Jul 22, 2026

Cholesterol Efflux Assay
Published on: March 6, 2012
Stress, stress reduction and hypercholesterolemia in African Americans: a review
R Calderon1, R H Schneider, C N Alexander
1Department of Psychology, Maharishi University of Management. College of Vedic Medicine, Fairfield, IA 52557, USA.
Insights
Psychological stress impacts coronary heart disease (CHD) risk factors in African Americans. The Transcendental Meditation technique effectively reduces these risks, offering a valuable behavioral intervention for this population.
Area of Science:
- Cardiology
- Psychology
- Public Health
Background:
- Psychological stress is linked to high coronary heart disease (CHD) rates and risk factors in African Americans.
- Stress can elevate serum lipids and is associated with clinical coronary events.
- Mechanisms linking stress to lipid alterations involve hormonal and dietary pathways.
Purpose of the Study:
- To explore the role of stress in CHD risk factors among African Americans.
- To evaluate non-drug behavioral interventions for hypercholesterolemia and other CHD risk factors.
- To assess the efficacy of the Transcendental Meditation technique as a stress-reduction approach for CHD prevention.
Main Methods:
- Review of existing research on psychological stress and cardiovascular health.
- Analysis of studies on behavioral interventions for hypercholesterolemia.
- Examination of data on the Transcendental Meditation technique's impact on CHD risk factors.
Main Results:
- Psychological stress contributes to elevated serum lipids and coronary events.
- Non-drug behavioral methods are recommended for hypercholesterolemia management.
- Transcendental Meditation reduces major CHD risk factors, including high cholesterol, blood pressure, and smoking.
Conclusions:
- Behavioral interventions can modify CHD morbidity and mortality.
- The Transcendental Meditation technique is an effective stress-reduction method.
- Stress reduction approaches like Transcendental Meditation may benefit African Americans in managing CHD risk factors.
Abstract:
Psychological stress may directly contribute to the disproportionately high rates of coronary heart disease morbidity and mortality and its etiologic risk factors in African Americans. Specifically, acute and chronic stress have been shown to raise serum lipids and are associated with clinical coronary events. The mechanisms by which stress contributes to alterations in lipid levels are not fully known, but various pathways (ie, hormonal, dietary, etc) have been implicated. Traditional methods for reducing blood serum lipids include diet, drugs or both. These methods have been criticized because of issues of compliance, side effects, and cost. Because of these limitations, nondrug behavioral methods are recommended by the National Cholesterol Education Program as the first line of prevention and treatment for hypercholesterolemia and other risk factors. Research shows that CHD morbidity and mortality and major risk factors may be modifiable by behavioral intervention. Specifically, the Transcendental Meditation technique, an effective antidote to stress, reduces levels of major CHD risk factors including hypercholesterolemia, as well as blood pressure and smoking. Using an effective stress reduction approach for prevention and treatment of CHD and its risk factors in African Americans may prove to be a valuable asset for this underserved population.
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