Related Experiment Videos
Trimethoprim-sulfamethoxazole-induced tremor in an immunocompetent patients
R G Patterson1, R L Couchenour
1Saint Louis University Belleville Family Practice, Missouri, USA.
Abstract:
Trimethoprim-sulfamethoxazole (TMP-SMX) is a widely administered antibiotic that is well tolerated by most patients. Hypersensitivity reactions and gastrointestinal intolerance are the most common adverse events associated with it. Central nervous system adverse effects such as tremors are less common and occur primarily in patients with acquired immune deficiency syndrome. A 29-year-old immunocompetent man developed a tremor while taking TMP-SMX. The tremor resolved within 2 days after the drug was discontinued.
Insights
Trimethoprim-sulfamethoxazole (TMP-SMX) can cause tremors, a rare central nervous system side effect. This study documents a tremor in an otherwise healthy individual, resolving after discontinuing the antibiotic.
Area of Science:
- Pharmacology
- Neurology
- Infectious Diseases
Background:
- Trimethoprim-sulfamethoxazole (TMP-SMX) is a commonly prescribed antibiotic.
- Most patients tolerate TMP-SMX well, with hypersensitivity and GI issues being common adverse events.
- Central nervous system (CNS) effects, like tremors, are infrequent and typically seen in immunocompromised individuals.
Observation:
- A 29-year-old immunocompetent male patient presented with tremor.
- The tremor developed during treatment with TMP-SMX.
- The patient had no underlying immune deficiencies.
Findings:
- The patient experienced a tremor attributed to TMP-SMX.
- The tremor resolved spontaneously within two days of discontinuing the antibiotic.
- This case highlights a potential neurological side effect in an immunocompetent patient.
Implications:
- TMP-SMX may cause tremors in immunocompetent individuals, though rare.
- Clinicians should consider TMP-SMX as a potential cause of tremors, even in patients without immune compromise.
- Further investigation into the mechanisms of TMP-SMX-induced neurological side effects is warranted.