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Prevention of cisplatin-induced nephrotoxicity by methimazole

A M Osman1, E M El-Sayed, E El-Demerdash

  • 1Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Nasr City, Cairo, Egypt.

Pharmacological Research
|December 22, 1999
PubMed

Insights

Methimazole protects against cisplatin-induced kidney damage by reducing toxicity. This combination therapy maintains cisplatin's cancer-fighting ability, suggesting potential for further research.

Area of Science:

  • Nephrology
  • Pharmacology
  • Oncology

Background:

  • Cisplatin chemotherapy can cause kidney damage (nephrotoxicity), limiting its use.
  • Methimazole, an antithyroid drug, may offer protection against chemical-induced kidney injury.

Purpose of the Study:

  • To investigate cisplatin's nephrotoxic effects at the cellular level.
  • To evaluate methimazole's protective potential against cisplatin nephrotoxicity.
  • To assess the combined effect on cisplatin's anti-cancer activity.

Main Methods:

  • Rats received a therapeutic dose of cisplatin (7 mg/kg).
  • Methimazole (40 mg/kg) was administered 30 minutes prior to cisplatin.
  • Kidney function, DNA integrity, and histology were assessed.
  • Ehrlich ascites carcinoma (EAC)-bearing mice evaluated combined drug efficacy.

Main Results:

  • Cisplatin significantly increased serum creatinine, BUN, and kidney lipid peroxides.
  • Kidney DNA fragmentation and histological damage were observed post-cisplatin.
  • Methimazole pretreatment significantly reduced cisplatin-induced kidney damage.
  • Combined treatment retained cisplatin's cytotoxic effect in EAC-bearing mice.

Conclusions:

  • Methimazole demonstrates significant nephroprotection against cisplatin.
  • The combination therapy preserves cisplatin's anti-cancer efficacy.
  • This combination warrants further investigation for clinical application.

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