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Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
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Antiangiogenic agents

W D Klohs1, J M Hamby

  • 1Department of Drug Development, Parke-Davis Pharmaceutical Research, Warner-Lambert Company, Ann Arbor, MI 48105, USA.

Current Opinion in Biotechnology
|December 22, 1999
PubMed

Insights

New anti-angiogenic compounds show promise for cancer therapy. These agents target tumor blood vessel formation, potentially offering effective treatment with reduced side effects and drug resistance.

Area of Science:

  • Oncology
  • Vascular Biology
  • Drug Discovery

Background:

  • Tumor growth and metastasis depend on angiogenesis, the formation of new blood vessels.
  • Targeting angiogenesis offers a therapeutic strategy with potential for reduced toxicity and drug resistance compared to traditional chemotherapy.
  • Vascular endothelial cells (ECs) have a slow turnover rate, making them attractive targets for anti-cancer agents.

Purpose of the Study:

  • To identify and evaluate novel agents that inhibit tumor-induced angiogenesis.
  • To assess the anti-angiogenic and anti-tumor activities of new therapeutic compounds.

Main Methods:

  • Investigated small molecules and antibodies interfering with endothelial cell signaling, migration, and differentiation.
  • Reported on the anti-angiogenic and anti-tumor effects of three specific compounds: ZD4190, SU6668, and PD 0173073.

Main Results:

  • Three novel compounds (ZD4190, SU6668, PD 0173073) demonstrated significant and selective anti-angiogenic activity.
  • These compounds also exhibited notable anti-tumor activity in preclinical studies.

Conclusions:

  • The development of targeted anti-angiogenic agents represents a promising avenue for cancer treatment.
  • ZD4190, SU6668, and PD 0173073 are potential candidates for further investigation as anti-cancer therapeutics.

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