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Related Experiment Videos

Predicting protein three-dimensional structure.

J Moult1

  • 1Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, Rockville, MD 20850, USA. moult@umbi.umd.edu.

Current Opinion in Biotechnology
|December 22, 1999
PubMed
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Protein structure modeling is advancing, with improvements in comparative modeling and fold recognition. While ab initio prediction for fragments shows progress, challenges remain in full protein structure prediction.

Area of Science:

  • Computational Biology
  • Structural Bioinformatics
  • Biophysics

Background:

  • Protein structure prediction is crucial for understanding biological function.
  • The Critical Assessment of protein Structure Prediction (CASP) experiments provide a benchmark for evaluating prediction methods.
  • Current methods face challenges in accuracy and scalability.

Purpose of the Study:

  • To assess the state of the art in protein structure modeling.
  • To identify areas of progress and persistent challenges in the field.
  • To evaluate the practical utility of current protein modeling techniques.

Main Methods:

  • Analysis of results from CASP experiments.
  • Evaluation of comparative modeling techniques, including sequence alignment, sidechain orientation, and loop building.

Related Experiment Videos

  • Assessment of fold recognition methods, particularly sequence profile approaches.
  • Review of ab initio structure prediction for protein fragments.

    • Main Results:

    • Significant improvements in comparative modeling, though refinement remains challenging.
    • Enhanced sequence profile methods have boosted fold recognition accuracy.
    • Progress in ab initio prediction for short protein fragments (40-60 residues).
    • Alignment quality continues to be a limiting factor in model usefulness.

    Conclusions:

    • Protein structure modeling is maturing into a practical technology.
    • Useful models can now be generated for a substantial number of protein sequences.
    • Further advancements are needed to fully solve the ab initio protein structure prediction problem.