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Designed molecules that fold to mimic protein secondary structures
K D Stigers1, M J Soth, J S Nowick
1Department of Chemistry, 535B Rowland Hall, University of California, Irvine, CA 92697-2025, USA. kstigers@uci.edu.
Current Opinion in Chemical Biology
|December 22, 1999
Abstract:
Molecules that fold to mimic protein secondary structures have emerged as important targets of bioorganic chemistry. Recently, a variety of compounds that mimic helices, turns, and sheets have been developed, with notable advances in the design of beta-peptides that mimic each of these structures. These compounds hold promise as a step toward synthetic molecules with protein-like properties and as drugs that block protein-protein interactions.