Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Laser thrombolysis using long pulse frequency-doubled Nd:YAG lasers.

J A Viator1, S A Prahl

  • 1Oregon Graduate Institute, Portland, Oregon 97291, USA.

Lasers in Surgery and Medicine
|December 22, 1999
PubMed
Summary

Laser thrombolysis effectively clears blood clots, with ablation characteristics independent of pulse duration. This finding supports various laser systems for treating arterial occlusions like myocardial infarction.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optical properties of scattering and absorbing materials used in the development of optical phantoms at 1064 nm.

Journal of biomedical optics·2012
Same author

Limitations in measurement of subsurface temperatures using pulsed photothermal radiometry.

Journal of biomedical optics·2012
Same author

Drug delivery with microsecond laser pulses into gelatin.

Applied optics·2010
Same author

Double-integrating-sphere system for measuring the optical properties of tissue.

Applied optics·2010
Same author

Determining the optical properties of turbid mediaby using the adding-doubling method.

Applied optics·2010
Same author

Optical Photoacoustic Detection of Circulating Melanoma Cells In Vitro.

International journal of thermophysics·2010

Area of Science:

  • Biomedical Engineering
  • Medical Physics
  • Cardiovascular Research

Background:

  • Laser thrombolysis utilizes laser energy to ablate blood clots in occluded arteries.
  • Clinical applications include treating myocardial infarction using various laser systems.
  • Pulsed dye lasers (1-microsecond pulse duration) are clinically used for coronary artery clot removal.

Purpose of the Study:

  • To comparatively investigate the clot ablation characteristics of lasers with different pulse durations.
  • To measure and compare the ablation threshold and efficiency of Nd:YAG lasers (50-150 microseconds and 2-10 milliseconds) with a pulsed dye laser (1 microsecond).

Main Methods:

  • Utilized frequency-doubled Nd:YAG lasers (532 nm) and a pulsed dye laser (522 nm).
  • Employed gel phantoms and animal clots confined in silicone tubes.

Related Experiment Videos

  • Determined ablation threshold using fluorescence and bubble detection; ablation efficiency via spectrophotometry.

    • Main Results:

    • Ablation threshold for gel phantoms was consistent across all tested lasers at 17 ± 2 mJ/mm².
    • Ablation efficiency for gel phantoms was 1.7 ± 0.1 μg/mJ.
    • Clot ablation efficiency was measured at 2.9 ± 1.0 μg/mJ.

    Conclusions:

    • Laser ablation threshold and efficiency are independent of pulse duration across a wide range (1 microsecond to 10 milliseconds).
    • These findings suggest flexibility in selecting laser parameters for thrombolysis.
    • Supports the use of various laser systems for effective clot removal in cardiovascular interventions.