Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pulse nebulization in pneumatic devices.

L Gradoń1, T R Sosnowski, Z Podolec

  • 1Department of Chemical and Process Engineering, Warsaw University of Technology,Poland. gradon@ichip.pw.edu.pl.

International Journal of Occupational Safety and Ergonomics : JOSE
|December 22, 1999
PubMed
Summary

This study shows that a computer-controlled pulse nebulizer can improve aerosol delivery to the lungs. This pulsed generation system enhances the efficiency of delivering medications like salbutamol via aerosols.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The thermostated medical jet nebulizer: Aerosol characteristics.

International journal of pharmaceutics·2019
Same author

The effect of shear and extensional viscosities on atomization of Newtonian and non-Newtonian fluids in ultrasonic inhaler.

International journal of pharmaceutics·2015
Same author

Deactivation of the pulmonary surfactant dynamics by toxic aerosols and gases.

Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine·2002
Same author

Application of a fibrous electrostatic filter for treatment of diesel exhaust.

International journal of occupational safety and ergonomics : JOSE·2000
Same author

Deposition and retention of ultrafine aerosol particles in the human respiratory system. Normal and pathological cases.

International journal of occupational safety and ergonomics : JOSE·2000
Same author

Assessment of the pulmonary toxicity of inhaled gases and particles with physicochemical methods.

International journal of occupational safety and ergonomics : JOSE·1999

Area of Science:

  • Respiratory medicine
  • Aerosol science
  • Biomedical engineering

Background:

  • Effective delivery of inhaled medications is crucial for treating respiratory diseases.
  • Pneumatic nebulizers are common devices for aerosol generation.
  • Optimizing aerosol particle size and delivery efficiency remains a challenge.

Purpose of the Study:

  • To investigate the potential of a pulsed nebulization system for improving aerosol particle delivery.
  • To analyze the mass distribution and generation yield of aerosols under controlled conditions.
  • To evaluate the impact of computer-controlled valve timing on aerosol characteristics.

Main Methods:

  • Aerosols of saline, salbutamol, sodium cromoglicate, and dornase alfa were generated using a pneumatic nebulizer.

Related Experiment Videos

  • A computer-controlled attachment was used to create pulsed aerosol generation (valve opening times 50-800 ms).
  • Aerosol particle mass distribution and generation yield were measured under controlled air humidity.

    • Main Results:

    • The pulsed generation system demonstrated the ability to modify aerosol characteristics.
    • Specific valve opening times influenced particle size distribution and generation efficiency.
    • The system showed promise for controlled aerosol generation.

    Conclusions:

    • A computer-controlled pulsed nebulizer system offers a potential method to enhance aerosol particle delivery to the lungs.
    • This technology could improve the efficacy of inhaled therapies.
    • Further research is warranted to optimize parameters for clinical application.